About Us

The biorepository facility at the NCR Biotech Science Cluster is one of the largest and most varied research bioresource centre in India. The facility was established in 2015 to provide support to the DBT funded pregnancy cohort study - ”Interdisciplinary Group of Advanced Research Birth Outcomes, a DBT India Initiative (GARBH-INI)” at THSTI. In 2019, it was identified as a separate platform in the Translational Research Program (TRP) with a mandate to expand to other programs in the NCR Biotech Science Cluster and beyond. It hosts a wide array of biospecimen with detailed clinical and demographic information.

In 2020, the biorepository facility at the NCR Biotech Science Cluster was notified as one in the network biorepositories of National COVID-19 bioresource of well-phenotyped clinical samples by ICMR, Govt. of India.

Currently, biorepository facility archives > 1.6 million varied biospecimen from health/disease-based longitudinal cohorts for biomarker development/ validation and for seroprevalence studies (blood, serum, plasma, urine, saliva, placental tissue, NP/OP swabs, DNA & PBMCs etc.). The team facilitates the requesters on the study design based on sample availability and study objectives. All participant IDs are de-identified by the use of Unique Identification Code (UIC) and the archived biospecimen are also tagged with alphanumeric identifiers.

The facility holds accreditation under ISO 20387:2018, and is a proud member of the International Society for Biologicals and Environmental Repositories (ISBER).

Programs

Biospecimen

Services

Collaborations

Vision & Mission

Mission: To establish a high quality reliable resource of a wide-range of biospecimen for regulated use in new technology/product development in academia and industry to facilitate tranlational research in both clicnical and basic sciences globally.

Vision: To adhere to the best practices in providing reliable, retrievable, high quality biological resources and to facilitate capacity building in biobanking at a national level by means of training, collaboration and knowledge exchange.

Infrastructure

The Biorepository is housed in a 2966 square feet facility, which has been established as per the requirements of ISO 20387:2018 standard and ISBER best practices. Six separate rooms have been created to segregate different activities namely accessioning, nucleic acid isolation, biospecimen archival, COVID-19 biospecimen processing, PBMC isolation and documentation. All equipment is calibrated and validated as per the requirements of ISO 17025: 2017 standard from an accredited third party agency.

The facility is equipped with -80°C deep freezers (n=36), -20°C freezers (n=1), 5±3°C Refrigerator (n=2), Liquid Nitrogen Storage Tanks (n=9), Cryoshippers (n=4) and other biospecimen processing equipment such as Biosafety cabinets (n=3), Centrifuges (n=3), Incubators (n=2) & Spectrophotometer (n=1).

Services

NCR Biotech Science Cluster Biorepository provides services for biospecimen collection, processing & storage (Deep freezer/Liquid nitrogen/Room temperature) as per need. Under dissemination of knowledge, the facility provides training on collection, processing of varied biospecimen. The facility has also trained interested researchers on setting up research platforms at the study sites and institutional biorepositories as per the best practices.

Biospecimen Processing Facility

Peripheral blood mononuclear cell (PBMC) Isolation from whole blood
Nucleic acid (DNA) extraction, sera and plasma preparation from whole blood

Biospecimen Archival Facility

The facility has the capacity to store 2 ml aliquots of at least 1.6 million biospecimen. It is equipped with 36 deep freezers (-80°C) and 9 liquid nitrogen containers (-196°C) for archival at their optimum temperatures.

Training of Manpower on processing of samples and biorepository guidelines

The facility supports national development efforts by training personnel from the industry, academia etc. in the area of biobanking governing principles and policies.

Research Programs

Summary of biospecimen archived at the Biorepository


Clinical Cohorts* Types of samples No. of participants No. of aliquots archived No. of aliquots retrieved
GARBH-INI Cohort Serum, Plasma, DNA, Urine and Blood as PAX gene tubes, Placental tissues, cord blood samples, high vaginal swabs ~ 11300 ~ 1150000 ~ 32000
COVID-19 Consortia Serum, Plasma, NP/OP swabs, PBMCs ~ 8600 ~ 145000 ~ 21000
Paediatric Renal Biology Program Serum, Plasma, DNA, Urine and Blood as PAX gene tubes ~ 1020 ~ 27000 NIL
Gestational Diabetes Mellitus (GDM) Study Serum, Plasma ~ 1170 ~ 13000 ~ 270
Gall bladder Cancer Registry Bile fluid, Gall bladder biopsy ~ 30 ~ 125 ~ 20
DRIVEN 2020 Serum ~ 22535 ~ 61473 ~ 20
NEO-SEPSIS Cord Blood, Rectal and Vaginal Swabs, Rectal and Vaginal Isolates ~ 1700 ~ 8000 ~ 45

*GARBH-INI = 'interdisciplinary Group for Advance Research on BirtH outcomes - DBT INdia Initiative';
*DRIVEN 2020 = DBT's Resource of Indian Vaccine Epidemiology Network 2020;
*GIISER = Global Immunology & Immune Sequencing for Epidemic Response;

Collaborations

The Biorepository has established collaborations with academia, hospitals as well as private labs under various studies.

DBT COVID-19 Consortium

National Biopharma Mission

All India Institute of Medical Sciences, New Delhi

Safdarjung Hospital (VMMCSH)

National Institute of Immunology

Makunda Christian Leprosy and General Hospital

Civil Hospital Gurugram

Christian Medical College, Vellore

Medanta Hospital, Gurugram

ESIC Medical College and Hospital, Faridabad

Lok Nayak Jai Prakash Narayan (LNJP) Hospital, New Delhi

Committees

Various committees have been constituted for the proper functioning of the Biorepository Facility

Scientific Advisory Committee

Dr. Deepali Jain, Pathologist, AIIMS (Member)
Dr. Sudip Kumar Datta, Head Lab Medicine, AIIMS (Member)
Dr. Ekta Gupta, Microbiologist, ILBS (Member)
Chairperson – The Executive Director, THSTI
Member Secretary – Dr. Pallavi Kshetrapal, Associate Professor, THSTI

Access Control Committee (COVID-19)

Dr. V.S. Chauhan, Emeritus Scientist, ICGEB
Dr. Subrata Sinha, Professor & Head Department of Biochemistry, AIIMS, Delhi
Dr. Jyoti Logani, Scientist E, Department of Biotechnology (DBT)
Dr. Shinjini Bhatnagar, Professor of Eminence, THSTI
Dr. Pallavi Kshetrapal, Associate Professor, THSTI
Dr. Savita Singh, Junior Research Scientist,THSTI
Chairperson – Dr. V.S. Chauhan
Member Secretary – Dr. Pallavi Kshetrapal

Institutional Ethics Committee (Biomedical and Health Research)

Prof. Satinder Aneja, Professor, Sharda University
Prof. Subir Kumar Maulik, Emeritus Scientist, ICMR
Dr. Arti Kapil Professor, AIIMS New Delhi
Dr. Suvasini Sharma, Associate Professor, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital
Dr. Ujjayini Ray, Professor of History, Lady Shriram College for Women
Dr. Bhabatosh Das, Associate Professor, THSTI
Dr. Shailaja Sopory, Principal Scientist-II
Mr. Munawwar Naseem, Legal - Dua Associates
Ms. Jasmine Singh, Hotel Management Professional
Ms. Vidhya Krishnamoorthy, Technical Manager (Grants Coordinator)
Chairperson - Prof. Satinder Aneja
Member Secretary - Ms. Vidhya Krishnamoorthy

Institutional Biosafety Committee

Dr. Vinay Kumar Nandicoori, Director, CSIR-CCMB
Dr. Prasenjit Guchhait, Professor, RCB
Dr. Milan Surjit, Professor
Dr. Krishnamohan Atmakuri, Associate Professor
Dr. Bhabatosh Das, Associate Professor
Dr. Nitya Wadhwa, Associate Professor
Dr. Susmita Chaudhuri, Assistant Professor
Dr. Shailaja Sopory, Principal Scientist-II
Chairperson - Dr. Krishnamohan Atmakuri
Member Secretary – Dr. Milan Surjit

EHS Committee

Dr. Nisheeth Agarwal, Professor
Dr. Krishnamohan Atmakuri, Associate Professor
Dr. Nitya Wadhwa, Associate Professor
Dr. Susmita Chaudhuri, Assistant Professor
Dr. Dinesh Mahajan, Principal Scientist-II
Mr. Vishal Gupta, Instrumentation Engineer
Mr. Narender Sharma, Senior Technical Officer (Civil)
Dr. Meenakshi Sharma, Executive Assistant
Chairperson – Dr. Nisheeth Agarwal
Co-chairperson - Dr. Susmita Chaudhuri
Member Secretary – Mr. Vishal Gupta

Team

A strong team comprising field experts contributing to the overall quality and success of the Biorepository Facility

Governance

Professor G. Karthikeyan

Executive Director

Dr. Shinjini Bhatnagar

Distinguished Professor

Dr. Pallavi Kshetrapal

Associate Professor & Faculty In-Charge

Scientific

Dr. Pallavi Kshetrapal

Associate Professor & Faculty In-Charge

Dr. Savita Singh

Jr. Research Scientist

Technical

Ajay Kumar

Senior Technical Officer

Dr. Tahreem Sahar

Technical Officer-I

Amit Kumar

Laboratory Technician

Ekta

Laboratory Technician

Vinod

Technical Assistant

Rashmi

Technical Assistant

Sachin Kumar

Laboratory Technician

Ajay

Lab Technician

Aakash

Lab Technician

Quality Manangement

Zafar Abbas

Quality Assurance Manager

Priyanka Saraswat

Quality Manager

Data & Biorepository Information Management

Prem Pratap Singh

Technical Assistant

Tarun Barkoti

Data Entry Officer

Pricing

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Free

$0 / month

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Developer

$29 / month

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Advanced

Ultimate

$49 / month

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Frequently Asked Questioins

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Contact

How to Use THSTI Biorepository Services?

For any enquiries and queries, Contact :

Our Address

Translational Health Science and Technology Institute (THSTI)
NCR Biotech Science Cluster,
3rd Milestone, Faridabad-Gurgaon Expressway,
Faridabad - Haryana 121001, INDIA

Email Us

biorepository@thsti.res.in
savitasingh@thsti.res.in

Call Us

+91 129 2876341
+91 129 2876198